![]() The reduction in endoscopic swallowing scores in the capsaicin group was significantly greater than in the placebo group 30 and 60 minutes after treatment (P <. 9Īlso, preliminary findings suggest the utility of topical capsaicin (0.025%), applied to the external auditory canal, for improving swallowing function in a study of elderly patients with dysphagia (n = 20). 02) and global subjective improvement (P =. In a randomized study (n = 30), topical capsaicin (0.075%) applied 3 times daily for 6 weeks (used along with standard treatment) yielded significant improvements in myalgic score (P =. ![]() 8Ĭapsaicin has been shown to have short-term benefits in patients with fibromyalgia as well. 7Ī meta-analysis of 25 randomized trials reported the capsaicin patch to be as effective as oral agents such as duloxetine and gabapentin for painful diabetic peripheral neuropathy without the adverse effects associated with these agents. In a phase IV multicenter study involving 420 patients with nondiabetic peripheral neuropathic pain, the capsaicin patch produced rapid, sustained pain relief and improved health-related quality of life (half of all patients achieved a clinically important ≥ 30% reduction in mean numerical pain rating scores ‘average pain’ by weeks 2 and 8 after the first treatment, which was sustained in patients who received retreatment). Furthermore, the reductions in pain were maintained with repeated administrations over 1 year. A 4-week randomized trial of 44 patients with postherpetic neuralgia found a single 60-minute application to be safe and effective in reducing the numerical pain rating scores compared with the control (P =. 5Ī high-concentration dermal patch containing 8% capsaicin has also been investigated for its benefits. 3 Topical capsaicin is also included in the American College of Rheumatology recommendations for osteoarthritis, 4 but its effectiveness for rheumatoid arthritis remains inconclusive. Gubili is Editor, Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, New York.Ĭlinical data indicate the benefits of topical formulations containing low-concentration capsaicin (0.025%) for psoriasis 1 (0.025%–0.3%) for prurigo nodularis 2 and (0.006%) for pruritus ani. Latte-Naor is Director, Mind-Body Medicine, and Assistant Attending Physician, Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, New York.
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